![]() Objective Elevated serum IgG4 levels are an important hallmark for diagnosing IgG4-related disease ( IgG4-RD), but can also be observed in other diseases. Wang, Chenqiong Wu, Xuefen Miao, Ye Xiong, Hui Bai, Lin Dong, Lingli This study concludes that sub maximal aerobic activity does not affect on serum IgG concentration and there is no concern for athletes and coaches that sub maximal aerobic activity can impair immune function.ĭetection of Serum IgG4 Levels in Patients with IgG4-Related Disease and Other Disorders The results showed that aerobic activity not significantly effect on Serum IgG concentration (p=0.357. Changes in serum IgG concentration in pre-test and post-test were analyzed by dependent t-test using spss software. Blood samples were obtained from subjects before and after aerobic activity. Aerobic activity was performed on bicycle ergometer for 30 minutes at intensity of 70 to 75 percent of maximum heart rate. Consequently, 10 male physical education students with age ranging from 21 to 24 years old and mean body mass index 22.22 kg m2 volunteered to participate in this study. PMID:2148668Įffects of aerobic activity on serum IgG concentration in male physical education studentsĭirectory of Open Access Journals (Sweden)įull Text Available The aim of this study was to investigate the effects of aerobic activity on Serum IgG concentration. This study suggests that selenium has an immunoregulatory effect, which might be of importance in both basic research and clinical practice. ![]() This effect was not related to age, as among children over the age of 6 years the serum concentrations of IgG2 and IgG4 had decreased significantly one year after the treatment had been stopped. Selenium had a significant augmentative effect on the serum concentrations of IgG2 and IgG4, but not of IgG1 and IgG3. In the present study the concentrations of the four IgG subclasses were measured in 29 of these children in samples of serum obtained before and immediately after the period of supplementation and one year after it had finished. In a previous study on children with Down's syndrome a reduced rate of infections was reported by their parents after the children had received six months' treatment with selenium supplements. Increase in serum concentrations of IgG2 and IgG4 by selenium supplementation in children with Down's syndrome.Īnnerén, G Magnusson, C G Nordvall, S L Further studies are needed to confirm the potential influence of atopy status on serum IgG4 concentrations. Conclusions Studies aimed at defining reference IgG4 values should consider partitioning by age and sex. Cases of IgG4-related disease were neither present at baseline nor detected after a median of 11 years of follow-up. Serum IgG4 concentrations were not significantly correlated with total eosinophil blood count. Serum IgG4 concentrations tended to be higher in atopics (individuals with IgE-mediated sensitization to aeroallergens) than in non-atopics, particularly among atopics without respiratory symptoms. Serum IgG4 concentrations were significantly correlated with IgE concentrations. Serum IgG4 concentrations were not significantly correlated with serum concentrations of proinflammatory cytokines and inflammation markers. After adjusting for age and sex, serum IgG4 concentrations were not significantly influenced by alcohol consumption, smoking or common metabolic abnormalities (obesity and the related metabolic syndrome). Serum IgG4 concentrations were significantly higher in males than in females and decreased with age. Five out of the 413 individuals (1.2%) exhibited IgG4 concentrations >135 mg/dL, and 17 out of 411 (4.1%) exhibited an IgG4/total IgG ratio >8%. Results Median IgG4 concentration was 26.8 mg/dL. Methods Serum IgG4 concentrations were measured with a commercial assay in 413 individuals (median age 55 years, 45% males) who were randomly selected from a general adult population. The aim of this study was to investigate serum IgG4 concentrations in adults and their potential relationship with demographic, lifestyle, metabolic, and allergy-related factors. Serum Concentrations of IgG4 in the Spanish Adult Population: Relationship with Age, Gender, and AtopyĬarballo, Iago Alvela, LucÃa Pérez, Luis-Fernando Gude, Francisco Vidal, Carmen Alonso, Manuela Sopeña, Bernardo Gonzalez-Quintela, Arturoīackground and Aim Serum IgG4 concentrations are commonly measured in clinical practice.
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